Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing

In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. T...

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Bibliographic Details
Published in:The Journal of immunology (1950) 1998-01, Vol.160 (2), p.1001-1006
Main Authors: Malinda, K M, Sidhu, G S, Banaudha, K K, Gaddipati, J P, Maheshwari, R K, Goldstein, A L, Kleinman, H K
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - physiology
Administration, Topical
Amino Acid Sequence
Animals
Cell Movement - drug effects
Cell Movement - immunology
Cells, Cultured
Endothelium, Vascular - cytology
Endothelium, Vascular - immunology
Female
Humans
Injections, Intraperitoneal
Injections, Subcutaneous
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Neovascularization, Physiologic - drug effects
Neovascularization, Physiologic - immunology
Rats
Thymosin - administration & dosage
Thymosin - analogs & derivatives
Thymosin - physiology
Umbilical Veins
Wound Healing - drug effects
Wound Healing - immunology
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Summary:In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. Talpha1, a 28 amino acid peptide initially isolated from the thymus, enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro. In vivo, Talpha1 stimulated angiogenesis in a subcutaneous model. When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Talpha1 promotes angiogenesis and wound healing.
ISSN:0022-1767