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Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing
In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. T...
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| Published in: | The Journal of immunology (1950) 1998-01, Vol.160 (2), p.1001-1006 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1006 |
| container_issue | 2 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 160 |
| creator | Malinda, K M Sidhu, G S Banaudha, K K Gaddipati, J P Maheshwari, R K Goldstein, A L Kleinman, H K |
| description | In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. Talpha1, a 28 amino acid peptide initially isolated from the thymus, enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro. In vivo, Talpha1 stimulated angiogenesis in a subcutaneous model. When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Talpha1 promotes angiogenesis and wound healing. |
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We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. Talpha1, a 28 amino acid peptide initially isolated from the thymus, enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro. In vivo, Talpha1 stimulated angiogenesis in a subcutaneous model. When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Talpha1 promotes angiogenesis and wound healing.</description><identifier>ISSN: 0022-1767</identifier><identifier>PMID: 9551940</identifier><language>eng</language><publisher>United States</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Adjuvants, Immunologic - physiology ; Administration, Topical ; Amino Acid Sequence ; Animals ; Cell Movement - drug effects ; Cell Movement - immunology ; Cells, Cultured ; Endothelium, Vascular - cytology ; Endothelium, Vascular - immunology ; Female ; Humans ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Neovascularization, Physiologic - drug effects ; Neovascularization, Physiologic - immunology ; Rats ; Thymosin - administration & dosage ; Thymosin - analogs & derivatives ; Thymosin - physiology ; Umbilical Veins ; Wound Healing - drug effects ; Wound Healing - immunology</subject><ispartof>The Journal of immunology (1950), 1998-01, Vol.160 (2), p.1001-1006</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9551940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malinda, K M</creatorcontrib><creatorcontrib>Sidhu, G S</creatorcontrib><creatorcontrib>Banaudha, K K</creatorcontrib><creatorcontrib>Gaddipati, J P</creatorcontrib><creatorcontrib>Maheshwari, R K</creatorcontrib><creatorcontrib>Goldstein, A L</creatorcontrib><creatorcontrib>Kleinman, H K</creatorcontrib><title>Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>In wound healing, lymphoid cells release soluble factors that attract fibroblasts and macrophages, initiating repair, endothelial cell migration, angiogenesis, and matrix production. 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We analyzed the effect of thymosin alpha1 (Talpha1) on endothelial cell migration, angiogenesis, and wound healing. Talpha1, a 28 amino acid peptide initially isolated from the thymus, enhanced the morphologic differentiation of endothelial cells and was a potent chemoattractant for endothelial cells and monocytes in vitro. In vivo, Talpha1 stimulated angiogenesis in a subcutaneous model. When given either topically or i.p., it accelerated wound healing in a punch model, demonstrating that Talpha1 promotes angiogenesis and wound healing.</abstract><cop>United States</cop><pmid>9551940</pmid><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of immunology (1950), 1998-01, Vol.160 (2), p.1001-1006 |
| issn | 0022-1767 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - physiology Administration, Topical Amino Acid Sequence Animals Cell Movement - drug effects Cell Movement - immunology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - immunology Female Humans Injections, Intraperitoneal Injections, Subcutaneous Mice Mice, Inbred C57BL Molecular Sequence Data Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - immunology Rats Thymosin - administration & dosage Thymosin - analogs & derivatives Thymosin - physiology Umbilical Veins Wound Healing - drug effects Wound Healing - immunology |
| title | Thymosin alpha 1 stimulates endothelial cell migration, angiogenesis, and wound healing |
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