CLINICAL EFFICACY OF IMIPENEM/CILASTATIN SODIUM IN PATIENTS WITH RESPIRATORY TRACT INFECTIONS CAUSED BY PSEUDOMONAS AERUGINOSA

The clinical utility of imipenem/cilastatin sodium (IPM/CS, Tienam®) was studied in 9 patients with respiratory tract infections from whomPseudomonas aeruginosawas isolated using transtracheal aspiration. The patients treated were 6 males and 3 females, with ages between 42 and 78 years. The infecti...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1990/01/25, Vol.43(1), pp.9-13
Main Authors: MIKASA, KEIICHI, SAWAKI, MASAYOSHI, KONISHI, MITSURU, NARITA, NOBUHIRO
Format: Article
Language:Japanese
Subjects:
Adult
Aged
Cilastatin - therapeutic use
Drug Combinations - therapeutic use
Female
Humans
Imipenem - therapeutic use
Lung Neoplasms - complications
Male
Middle Aged
Pseudomonas aeruginosa - drug effects
Pseudomonas Infections
Respiratory Tract Infections - drug therapy
Stomach Neoplasms - complications
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Summary:The clinical utility of imipenem/cilastatin sodium (IPM/CS, Tienam®) was studied in 9 patients with respiratory tract infections from whomPseudomonas aeruginosawas isolated using transtracheal aspiration. The patients treated were 6 males and 3 females, with ages between 42 and 78 years. The infections diagnosed were chronic bronchitis in 5 patients, diffuse panbronchiolitis in 2 and bronchopneumonia in 2.P. aeruginosaalone was isolated from 6 patients and concomitantly with other organisms from 3. Clinical efficacy was good in 6 patients, fairly good in 1 and poor in 2. No side effects or abnormal laboratory test values were observed, except for a slight elevation of LDH in 1 patient. From these results, it appears that IPM/CS is a clinically useful antibiotic for the treatment of respiratory tract infections caused byP. aeruginosa.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.43.9