No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients

Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (ϵ4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE ϵ4 allele. Our data indicate...

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Bibliographic Details
Published in:Schizophrenia research 1998-03, Vol.30 (2), p.149-153
Main Authors: Thibaut, Florence, Coron, Beatrice, Hannequin, Didier, Segard, Laetitia, Martin, Cosette, Dollfus, Sonia, Campion, Dominique, Frebourg, Thierry, Petit, Michel
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Alleles
Apolipoprotein E
Apolipoproteins E - genetics
Biological and medical sciences
Case-Control Studies
Chi-Square Distribution
Cognition Disorders - genetics
Cognitive impairment
Female
Genetic Markers
Humans
Male
Medical sciences
Middle Aged
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - complications
Schizophrenia - genetics
Schizophrenic Psychology
Wechsler Scales
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Summary:Given the strong association of the apolipoprotein E (apoE) allele epsilon 4 (ϵ4) with Alzheimer's disease or cognitive decline in elderly, we tested whether cognitive performance in schizophrenic subjects is associated with an increase in the frequency of the ApoE ϵ4 allele. Our data indicate that in our sample: (1) there is no association between schizophrenia and the ApoE ϵ4 allele; and (2) the ApoE ϵ4 allele is not of major importance with regard to the cognitive decline observed in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(97)00147-3