Biliary Tract Cancer Accompanied by Anomalous Junction of Pancreaticobiliary Ductal System in Adults

• Published in: The American journal of surgery 1998-03, Vol.175 (3), p.218-220
• Main Authors: Tanaka, Koki, Ikoma, Akira, Hamada, Nobuo, Nishida, Seigo, Kadono, Jun, Taira, Akira
• Format: Article
• Language: English
• Subjects: Abdomen; Acids; Adenocarcinoma - complications; Adenocarcinoma - surgery; Adenocarcinoma, Papillary - complications; Adenocarcinoma, Papillary - surgery; Adult; Aged; Bile ducts; Bile Ducts - abnormalities; Biliary tract; Biliary tract diseases; Biliary Tract Neoplasms - complications; Biliary Tract Neoplasms - surgery; Biological and medical sciences; Cancer; Cholangiocarcinoma; Cholecystectomy; Congenital anomalies; Cysts; Female; Gallbladder; Gallbladder cancer; Gallstones; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Lymph nodes; Lymphatic system; Male; Malformations; Malignancy; Medical prognosis; Medical sciences; Metastases; Metastasis; Middle Aged; Pancreatic Ducts - abnormalities; Pathogenesis; Patients; Retrospective Studies; Tumors
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/S0002-9610(97)00288-2

Background: Anomalous junction of the pancreaticobiliary ductal system (AJPBDS) is a congenital anomaly in which the junction is located outside the duodenal wall. Recently, attention has been focused on the high incidence of malignancy in this anomaly. The purpose of this study was to clarify the clinicopathological features of this anomaly and to determine the appropriate surgical approach for biliary tract cancer associated with AJPBDS. Methods: The data for 38 patients with AJPBDS, including 14 who had been treated for biliary tract cancer (2 with bile duct cancer and 12 with gallbladder cancer), were retrospectively reviewed. We assessed the clinical features, characteristics of the tumor, operative procedure, and outcome for each patient. Results: The incidence of malignancy in AJPBDS was 17.8% (2 patients with bile duct cancer and 3 with gallbladder cancer) in the bile duct dilatation group (n = 28) and 90% (9 patients with gallbladder cancer) in the no-dilatation group (n = 10). The mean length of the common channel was 24.7 mm (range 20 to 35 mm). Resection with lymphadenectomy was performed in 9 (64.3%) of 14 patients, and curative resection in 5 of these 9 patients. Ten (71%) of the 14 patients had lymph node involvement noted either at the time of initial diagnosis or at surgery. The incidence of lymph node metastasis was closely related to the depth of tumor involvement. Ten patients died of recurrence or primary cancer, from 3 to 30 months after operation. Four patients are still alive without recurrent disease from 2.5 to 13 years after operation. Conclusion: For patients with AJPBDS without bile duct dilatation, prophylactic cholecystectomy is recommended even if no malignant lesion is found in the gallbladder because of the high incidence of gallbladder cancer and the poor prognosis. Both early detection and curative resection of the tumor are essential for successful treatment of biliary tract cancer.