Fulminant hepatitis due to herpes simplex virus-type 2 in early phase of bone marrow transplantation

Hepatitis due to Herpes Simplex Virus (HSV) is a rare and severe infection in patients with impaired immunity, as bone marrow transplanted. The antemortem diagnosis is often difficult to establish because the clinical features are nonspecific. We report an uncommon cause of fulminant hepatic failure...

Full description

Saved in:
Bibliographic Details
Published in:Hematology and cell therapy 1998-02, Vol.40 (1), p.41-44
Main Authors: GRUSON, D, HILBERT, G, LE BAIL, B, PORTEL, L, BOIRON, J.-M, REIFFERS, J, GBIKPI-BENISSAN, G
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Bone marrow, stem cells transplantation. Graft versus host reaction
Hepatitis, Viral, Human - etiology
Hepatitis, Viral, Human - pathology
Hepatitis, Viral, Human - virology
Herpesvirus 2, Human - isolation & purification
Human viral diseases
Humans
Infectious diseases
Liver - pathology
Liver - virology
Male
Medical sciences
Myelodysplastic Syndromes - therapy
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Viral diseases
Viral hepatitis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatitis due to Herpes Simplex Virus (HSV) is a rare and severe infection in patients with impaired immunity, as bone marrow transplanted. The antemortem diagnosis is often difficult to establish because the clinical features are nonspecific. We report an uncommon cause of fulminant hepatic failure in a neutropenic patient, 14 days after bone marrow transplantation. HSV-2 fulminant hepatitis occurred during acyclovir prophylactic treatment. No observation of HSV hepatitis in this context has been reported since prophylaxis is used. Because of the extremely high apparent mortality associated with HSV hepatitis, and the improved survival noted among the non-marrow-transplant recipients and prolonged survival seen in one marrow transplant recipient, it seems reasonable to urge early and aggressively acyclovir therapy. A liver biopsy seems to be indispensable in the case of hepatic failure in post-marrow-transplantation in order to make rapidly a diagnosis.
ISSN:1269-3286
1279-8509