Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis

Recent studies indicate that nonsteroidal anti-inflammatory drugs have a chemopreventive effect against colorectal neoplasia. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenases, principal enzymes that mediate the formation of prostanoids. To determine whether prostanoids are involved in th...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1998-04, Vol.58 (8), p.1750-1753
Main Authors: YANG, V. W, SHIELDS, J. M, HAMILTON, S. R, SPANNHAKE, E. W, HUBBARD, W. C, HYLIND, L. M, ROBINSON, C. R, GIARDIELLO, F. M
Format: Article
Language:English
Subjects:
6-Ketoprostaglandin F1 alpha - metabolism
Adenoma - genetics
Adenoma - metabolism
Adenomatous Polyposis Coli - genetics
Adenomatous Polyposis Coli - metabolism
Adult
Biological and medical sciences
Dinoprost - metabolism
Dinoprostone - metabolism
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Mucosa - metabolism
Male
Medical sciences
Oxytocics - metabolism
Prostaglandin D2 - metabolism
Prostaglandins - metabolism
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Thromboxane B2 - metabolism
Tumors
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Summary:Recent studies indicate that nonsteroidal anti-inflammatory drugs have a chemopreventive effect against colorectal neoplasia. Nonsteroidal anti-inflammatory drugs inhibit cyclooxygenases, principal enzymes that mediate the formation of prostanoids. To determine whether prostanoids are involved in the pathogenesis of colorectal adenomas, we compared the levels of five major stable metabolic products of the cyclooxygenase pathway in the normal-appearing mucosa and in adenomas of patients with familial adenomatosis polyposis. Of 12 patients tested, 6 had elevated levels of at least one prostanoid in the adenomas. More importantly, the relative levels of three prostanoids [prostaglandin (PG)D2, PGE2, and 6-keto-PGF1alpha] were elevated in adenomas compared to normal-appearing mucosa from the same patients, and the resulting ratios were correlated with the size of the adenoma. These results suggest a role for prostanoids in progression of colorectal polyposis in familial adenomatosis polyposis patients.
ISSN:0008-5472
1538-7445