Fetal adrenal transplants respond to ACTH and prevent addisonian crisis in adrenalectomized rats

The present study investigates whether fetal adrenal transplants into the omentum of adrenalectomized rats will be integrated into the recipient's endocrine system to provide competent adrenocortical function. The results demonstrate that fetal adrenals graft with a rich vascular supply, mature...

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Bibliographic Details
Published in:Pediatric surgery international 1998-04, Vol.13 (4), p.271-273
Main Authors: TILL, H, KELLNAR, S, STRASSBURGER, C. J, SCHWARZ, H. P, BARRETTON, G, JOPPICH, I
Format: Article
Language:English
Subjects:
Adrenal Glands - embryology
Adrenalectomy
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adrenocorticotropic Hormone - blood
Animals
Biological and medical sciences
Endocrinopathies
Female
Fetal Tissue Transplantation
Medical sciences
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary-Adrenal System - physiology
Rats
Rats, Inbred Lew
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Summary:The present study investigates whether fetal adrenal transplants into the omentum of adrenalectomized rats will be integrated into the recipient's endocrine system to provide competent adrenocortical function. The results demonstrate that fetal adrenals graft with a rich vascular supply, mature histologically, and produce increasing levels of corticosterone. When bilateral adrenalectomy is performed in the recipient, survival is prolonged and addisonian crisis can be prevented. Moreover, adrenocorticotrophic hormone levels decrease with increasing levels of corticosterone, indicating that the fetal grafts are integrated into the physiological pituitary-adrenocortical feedback system.
ISSN:0179-0358
1437-9813
DOI:10.1007/s003830050314