Integrin signaling and cell growth control

Integrins contribute to cell growth by providing a physical linkage between cytoskeletal structures and the extracellular matrix, and also by participating in various signal transduction processes. The interaction of integrins with matrix ligands can generate signals in and of itself, and can also m...

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Bibliographic Details
Published in:Current opinion in cell biology 1998-04, Vol.10 (2), p.220-231
Main Authors: Howe, Alan, Aplin, Andrew E, Alahari, Suresh K, Juliano, RL
Format: Article
Language:English
Subjects:
Animals
Cell Division - physiology
Cytoskeleton - metabolism
Cytoskeleton - physiology
Growth Substances - physiology
Humans
Integrins - physiology
Models, Biological
Signal Transduction - physiology
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Summary:Integrins contribute to cell growth by providing a physical linkage between cytoskeletal structures and the extracellular matrix, and also by participating in various signal transduction processes. The interaction of integrins with matrix ligands can generate signals in and of itself, and can also modulate signals instigated by soluble factors such as peptide mitogens. Cellular events affected by integrin-mediated signaling include motility, cell division, differentiation and programmed cell death. Elucidation of how integrin-mediated cell adhesion controls cell growth is likely to be of fundamental importance in understanding complex biological processes, such as tissue morphogenesis and tumor progression.
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(98)80144-0