Successful Treatment of Severe Cytomegalovirus Infection with Ganciclovir in an Immunocompetent Host

Severe life-threatening infection due to cytomegalovirus (CMV) is rare in immunocompetent hosts. A recent review of the medical literature revealed severe CMV disease in only 34 previously healthy individuals. The use of specific antiviral therapy in these patients did seem to confer a survival adva...

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Bibliographic Details
Published in:Clinical infectious diseases 1998-04, Vol.26 (4), p.1007-1008
Main Authors: McCormack, Joseph G., Bowler, Simon D., Donnelly, J. Elizabeth, Steadman, Charles
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - therapeutic use
Antivirals
Atrial fibrillation
Biological and medical sciences
Blood
Brief Reports
Cytomegalovirus
Cytomegalovirus infections
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - physiopathology
Cytomegalovirus Infections - virology
Diseases
Echocardiography
Ganciclovir - therapeutic use
Hepatitis, Viral, Human - drug therapy
Hepatitis, Viral, Human - physiopathology
Hepatitis, Viral, Human - virology
Humans
Immunocompetence
Infections
Male
Medical sciences
Myocarditis
Myocarditis - drug therapy
Myocarditis - physiopathology
Myocarditis - virology
Pharmacology. Drug treatments
Pneumonia
Pneumonia - drug therapy
Pneumonia - physiopathology
Pneumonia - virology
Tropical medicine
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Summary:Severe life-threatening infection due to cytomegalovirus (CMV) is rare in immunocompetent hosts. A recent review of the medical literature revealed severe CMV disease in only 34 previously healthy individuals. The use of specific antiviral therapy in these patients did seem to confer a survival advantage; however, there are no guidelines or recommendations for the use of such therapy in this context. We describe a previously healthy patient with severe CMV myocarditis, pneumonitis, and hepatitis whose condition responded favorably to a 2-week course of iv ganciclovir.
ISSN:1058-4838
1537-6591
DOI:10.1086/517635