Hepatitis B Virus DNA in Persons with Isolated Antibody to Hepatitis B Core Antigen Who Subsequently Received Hepatitis B Vaccine

Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vacc...

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Bibliographic Details
Published in:Clinical infectious diseases 1998-04, Vol.26 (4), p.895-897
Main Authors: Silva, A. Eduardo, McMahon, Brian J., Parkinson, Alan J., Sjogren, Maria H., Hoofnagle, Jay H., Bisceglie, Adrian M. Di
Format: Article
Language:English
Subjects:
Antibodies
Biological and medical sciences
Clinical Articles
DNA, Viral - analysis
Dosage
Dose response relationship
Hepatitis Antibodies - isolation & purification
Hepatitis antigens
Hepatitis B
Hepatitis B Core Antigens - immunology
Hepatitis B vaccines
Hepatitis B Vaccines - immunology
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Polymerase chain reaction
Vaccination
Viral diseases
Viral hepatitis
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Summary:Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.
ISSN:1058-4838
1537-6591
DOI:10.1086/513918