Hepatitis B Virus DNA in Persons with Isolated Antibody to Hepatitis B Core Antigen Who Subsequently Received Hepatitis B Vaccine

Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vacc...

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Published in:Clinical infectious diseases 1998-04, Vol.26 (4), p.895-897
Main Authors: Silva, A. Eduardo, McMahon, Brian J., Parkinson, Alan J., Sjogren, Maria H., Hoofnagle, Jay H., Bisceglie, Adrian M. Di
Format: Article
Language:English
Subjects:
Antibodies
Biological and medical sciences
Clinical Articles
DNA, Viral - analysis
Dosage
Dose response relationship
Hepatitis Antibodies - isolation & purification
Hepatitis antigens
Hepatitis B
Hepatitis B Core Antigens - immunology
Hepatitis B vaccines
Hepatitis B Vaccines - immunology
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Polymerase chain reaction
Vaccination
Viral diseases
Viral hepatitis
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container_end_page 897
container_issue 4
container_start_page 895
container_title Clinical infectious diseases
container_volume 26
creator Silva, A. Eduardo
McMahon, Brian J.
Parkinson, Alan J.
Sjogren, Maria H.
Hoofnagle, Jay H.
Bisceglie, Adrian M. Di
description Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.
doi_str_mv 10.1086/513918
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source JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online
subjects Antibodies
Biological and medical sciences
Clinical Articles
DNA, Viral - analysis
Dosage
Dose response relationship
Hepatitis Antibodies - isolation & purification
Hepatitis antigens
Hepatitis B
Hepatitis B Core Antigens - immunology
Hepatitis B vaccines
Hepatitis B Vaccines - immunology
Hepatitis B virus
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Human viral diseases
Humans
Infections
Infectious diseases
Medical sciences
Polymerase chain reaction
Vaccination
Viral diseases
Viral hepatitis
title Hepatitis B Virus DNA in Persons with Isolated Antibody to Hepatitis B Core Antigen Who Subsequently Received Hepatitis B Vaccine
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