PRIOR EXPOSURE TO MK-801 SENSITIZES RATS TO ETHANOL-INDUCED CONDITIONED TASTE AVERSION

Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine [(+)MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.] significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05–0.2 mg/kg) produced only a marg...

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Bibliographic Details
Published in:Alcohol and alcoholism (Oxford) 1998-03, Vol.33 (2), p.116-120
Main Authors: BIENKOWSKI, PRZEMYSLAW, KOROS, ELIZA, PIASECKI, JERZY, KOSTOWSKI, WOJCIECH
Format: Article
Language:English
Subjects:
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Central Nervous System Depressants - pharmacology
Conditioning, Operant - drug effects
Discrimination (Psychology) - drug effects
Dizocilpine Maleate - pharmacology
Dose-Response Relationship, Drug
Ethanol - pharmacology
Excitatory Amino Acid Antagonists - pharmacology
Male
Medical sciences
Rats
Rats, Wistar
Taste - drug effects
Toxicology
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Summary:Pretreatment with an uncompetitive NMDA receptor antagonist, dizocilpine [(+)MK-801; six daily injections of 0.1 or 0.2 mg/kg, i.p.] significantly enhanced subsequent 1.5 g/kg ethanol-induced conditioned taste aversion (CTA). In a control experiment, dizocilpine (0.05–0.2 mg/kg) produced only a marginal CTA. Thus, pre-exposure to low, non-aversive doses of MK-801 may sensitize rats to the aversive stimulus effects of ethanol.
ISSN:0735-0414
1464-3502
DOI:10.1093/oxfordjournals.alcalc.a008366