Stroke in a Neonate Heterozygous for Factor V Leiden

Activated protein C resistance is the most common hereditary coagulation abnormality and is caused by the factor V Leiden mutation. A newborn who developed seizures within hours after delivery and was found to have a bihemispheric stroke is described. This patient, determined to be heterozygous for...

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Bibliographic Details
Published in:Pediatric neurology 1998-03, Vol.18 (3), p.262-264
Main Authors: Varelas, Panayiotis N, Sleight, Barbara J, Rinder, Henry M, Sze, Gordon, Ment, Laura R
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cerebrovascular Disorders - genetics
Factor V - genetics
Heterozygote
Humans
Infant, Newborn
Male
Medical sciences
Mutation
Neurology
Tomography, X-Ray Computed
Vascular diseases and vascular malformations of the nervous system
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Summary:Activated protein C resistance is the most common hereditary coagulation abnormality and is caused by the factor V Leiden mutation. A newborn who developed seizures within hours after delivery and was found to have a bihemispheric stroke is described. This patient, determined to be heterozygous for factor V Leiden, is the first reported case of neonatal stroke associated with this common mutation.
ISSN:0887-8994
1873-5150
DOI:10.1016/S0887-8994(97)00166-5