Gastric emptying of the liquid, solid and oil phase of a meal in normal volunteers and patients with Billroth II gastrojejunostomy

• Published in: European journal of clinical investigation 1998-03, Vol.28 (3), p.197-204
• Main Authors: MAES, B. D, HIELE, M. I, GEYPENS, B. J, GHOOS, Y. F, RUTGEERTS, P. J
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Breath test; Breath Tests; Case-Control Studies; Dietary Fats, Unsaturated - pharmacokinetics; dumping syndrome; Dumping Syndrome - etiology; Dumping Syndrome - physiopathology; Female; gastric emptying; Gastric Emptying - physiology; Gastroenterostomy - adverse effects; glycine; Humans; Jejunum - surgery; Male; Medical sciences; Middle Aged; octanoic acid; Stomach Ulcer - surgery; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1046/j.1365-2362.1998.00272.x

Background The relationship between gastric emptying of different phases of a meal in humans has only been partly studied in normal subjects and in patients with previous gastric surgery. Methods In the present study, gastric emptying of the liquid, solid and oil phase and the relationship between the phases was evaluated in 10 normal control subjects and in seven patients with Billroth II gastrojejunostomy using breath test technology. Results Gastric emptying in normal subjects showed a clear separation between the emptying of the liquid, solid and oil phase. In healthy volunteers, the liquid phase emptied in the same manner in the presence of a solid phase as in the presence of an oil phase. In contrast, the oil phase emptied more slowly with liquids than with solids. The emptying rate of the oil phase was not only inversely related to the amount administered but was also dependent on its chemical composition. Gastric emptying in patients with Billroth II gastroenterostomy was characterized by a complete loss of discrimination between the different phases of the meal, with an extremely fast emptying of the oil phase compared with normal control subjects. Conclusion In normal subjects, the liquid, solid and oil phase of a meal are emptied differently. In patients with Billroth II gastrojejunostomy, dumping of the oil phase is the most pronounced difference from the normal physiology of gastric emptying. This could be one of the reasons why Billroth II gastrectomy may be associated with fat malabsorption.