Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata

Licochalcone A, B, C, D and echinatin, retrochalcones isolated from the roots of Glycyrrhiza inflata (licorice), along with an ordinary chalcone isoliquiritigenin, were assessed for their inhibitory activities on lipid peroxidation in various systems and radical scavenging activity. Among those test...

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Published in:Bioorganic & medicinal chemistry 1998-03, Vol.6 (3), p.339-347
Main Authors: Haraguchi, Hiroyuki, Ishikawa, Harumi, Mizutani, Kenji, Tamura, Yukiyoshi, Kinoshita, Takeshi
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Chalcone - analogs & derivatives
Chalcone - pharmacology
Colorimetry
Free Radical Scavengers - pharmacology
Glycyrrhiza - chemistry
Humans
Lipid Peroxidation - drug effects
Male
Mice
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Plant Extracts - pharmacology
Plants, Medicinal
Rats
Rats, Wistar
Structure-Activity Relationship
Superoxides - metabolism
Xanthine Oxidase - metabolism
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Summary:Licochalcone A, B, C, D and echinatin, retrochalcones isolated from the roots of Glycyrrhiza inflata (licorice), along with an ordinary chalcone isoliquiritigenin, were assessed for their inhibitory activities on lipid peroxidation in various systems and radical scavenging activity. Among those tested, licochalcones B and D strongly inhibited superoxide anion production in the xanthine/xanthine oxidase system. These two compounds also showed potent scavenging activity on DPPH radical. Microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH was inhibited almost completely by 3 μg/ml of licochalcones B and D. Mitochondrial lipid peroxidation induced by Fe(III)-ADP/NADH was more sensitive to these retrochalcones; almost complete inhibition was observed at 10 μg/ml of all retorochalcones tested. Licochalcones B and D scavenged superoxide anion in microsome. Furthermore, these retrochalcones protected red cells against oxidative hemolysis. These phenolic compounds were shown to be effective to protect biological systems against various oxidative stresses.
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(97)10034-7