Consolidating the role of I-MIBG-scintigraphy in childhood neuroblastoma: five years of clinical experience

In recent years, *I-MIBG (*I-metaiodobenzylguanidine), which is transported and stored in the chromaffin cells, has been shown to allow good visualization of neuroblastomas in children. This paper deals with 30 *I-MIBG-scans performed in 20 children: 16 with neuroblastoma, 3 with retinoblastoma, and...

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Bibliographic Details
Published in:Pediatric radiology 1990, Vol.20 (3), p.157-159
Main Authors: JACOBS, A, DELREE, M, DESPRECHINS, B, OTTEN, J, FERSTER, A, JONCKHEER, M. H, MERTENS, J, HAM, H. R, PIEPSZ, A
Format: Article
Language:English
Subjects:
3-Iodobenzylguanidine
Adrenal Gland Neoplasms - diagnostic imaging
Biological and medical sciences
Child
Child, Preschool
Eye Neoplasms - diagnostic imaging
Female
Humans
Infant
Infant, Newborn
Iodine Radioisotopes
Iodobenzenes
Liver Neoplasms - diagnostic imaging
Liver Neoplasms - secondary
Male
Medical sciences
Methods
Neuroblastoma - diagnostic imaging
Neurology
Paraganglioma - diagnostic imaging
Radionuclide Imaging
Retinoblastoma - diagnostic imaging
Thoracic Neoplasms - diagnostic imaging
Tumors of the nervous system. Phacomatoses
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Summary:In recent years, *I-MIBG (*I-metaiodobenzylguanidine), which is transported and stored in the chromaffin cells, has been shown to allow good visualization of neuroblastomas in children. This paper deals with 30 *I-MIBG-scans performed in 20 children: 16 with neuroblastoma, 3 with retinoblastoma, and 1 with a malignant paraganglioma. A high detection rate was found for both primary and secondary sites of neuroblastoma. *I-MIBG was generally superior to 99mTc-MDP bone scintigraphy in the detection of bone metastases. Our experience illustrates the unique place of *I-MIBG-scintigraphy compared with other imaging techniques: it makes it possible to define the nature of the tumour, particularly in cases with normal catecholamine levels; to establish how extensive the lesions are at the time of diagnosis; and to confirm complete remission. No abnormal *I-MIBG uptake was noted in the 3 cases of retinoblastoma.
ISSN:0301-0449
1432-1998