Effects of intraseptal infusions of N-methyl- d-aspartate receptor ligands on memory in an object recognition task in rats

The present study describes the effects of intraseptal microinjections of N-methyl- d-aspartate (NMDA) or AP5, an agonist and an antagonist of the NMDA receptors, respectively, upon memory of rats. Animals were injected with the drug or vehicle immediately after the first exposure to two identical o...

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Bibliographic Details
Published in:Neuroscience letters 1998-03, Vol.244 (2), p.97-100
Main Authors: Puma, Carole, Baudoin, Claude, Bizot, Jean-Charles
Format: Article
Language:English
Subjects:
2-Amino-5-phosphonovalerate - administration & dosage
2-Amino-5-phosphonovalerate - pharmacology
Animals
AP5
Behavioral psychophysiology
Biological and medical sciences
Consolidation
Exploratory Behavior - drug effects
Exploratory Behavior - physiology
Fundamental and applied biological sciences. Psychology
Infusions, Parenteral
Learning
Ligands
Male
Memory - drug effects
Memory - physiology
N-Methyl- d-aspartate
N-Methylaspartate - administration & dosage
N-Methylaspartate - pharmacology
Neurotransmission and behavior
Object recognition
Pattern Recognition, Visual
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Wistar
Reaction Time
Receptors, N-Methyl-D-Aspartate - physiology
Septal Nuclei - drug effects
Septal Nuclei - physiology
Septum
Working memory
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Summary:The present study describes the effects of intraseptal microinjections of N-methyl- d-aspartate (NMDA) or AP5, an agonist and an antagonist of the NMDA receptors, respectively, upon memory of rats. Animals were injected with the drug or vehicle immediately after the first exposure to two identical objects, and the duration of exploration of the familiar and a new object were evaluated 45 min or 24 h later. Vehicle-treated rats explored the new object longer than the familiar object when the intertrial time was 45 min, indicating that they remembered the familiar object, but not when the intertrial time was 24 h. The difference of exploration time between the objects was increased by NMDA, but not by AP5, when the intertrial time was 24 h, and decreased by AP5 when the intertrial interval was 45 min. These results suggest that NMDA and AP5 improves and disrupts, respectively, the consolidation in a working memory task.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(98)00137-2