Calibration of a prototype in vivo total body composition analyser using 14 MeV neutron activation and the associated particle technique

A prototype in vivo total body composition analyser has been constructed for determining the total body contents of nitrogen (TBN), carbon (TBC) and oxygen (TBO) in young experimental animals such as sheep or pigs by 14 MeV neutron activation using a commercially available associated particle sealed...

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Bibliographic Details
Published in:Applied radiation and isotopes 1998-05, Vol.49 (5), p.537-539
Main Authors: Mitra, S., Wolff, J.E., Garrett, R.
Format: Article
Language:English
Subjects:
Animals
Body Composition
Body Weight
Calibration
Carbon - analysis
Gamma Rays
Humans
Neutron Activation Analysis - instrumentation
Neutron Activation Analysis - methods
Nitrates
Nitrogen - analysis
Oxygen - analysis
Phantoms, Imaging
Reference Values
Sheep
Swine
Urea
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Summary:A prototype in vivo total body composition analyser has been constructed for determining the total body contents of nitrogen (TBN), carbon (TBC) and oxygen (TBO) in young experimental animals such as sheep or pigs by 14 MeV neutron activation using a commercially available associated particle sealed tube neutron generator (APSTNG). The instrument was calibrated by scanning phantoms of different sizes in the mass range 10–36 kg, filled with a mixture of elements as found in a normal human body. Good agreement was found between the measured and expected values of N, O and C when two phantoms of similar dimensions but of different composition were scanned. With four 15 cm × 15 cm cross section and 45 cm long NaI(Tl) gamma detectors and a radiation dose of ≈ 20 μSv due to neutrons, the expected precisions for a 28 kg animal, CV% (based on counting statistics) are N: 9.3, C: 2.3 and O: 1.4.
ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(97)00070-5