Schizophrenia as a developmental disorder of the cerebral cortex

The hypothesis that schizophrenia results from a developmental, as opposed to a degenerative, process affecting the cerebral cortex has become popular in current thinking about the disorder. While many of the data gathered in support of this hypothesis do not in themselves represent conclusive proof...

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Bibliographic Details
Published in:Current opinion in neurobiology 1998-02, Vol.8 (1), p.157-161
Main Authors: Raedler, Thomas J, Knable, Michael B, Weinberger, Daniel R
Format: Article
Language:English
Subjects:
Cerebral Cortex - growth & development
Cerebral Cortex - pathology
Female
Humans
Pregnancy
Schizophrenia - pathology
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Summary:The hypothesis that schizophrenia results from a developmental, as opposed to a degenerative, process affecting the cerebral cortex has become popular in current thinking about the disorder. While many of the data gathered in support of this hypothesis do not in themselves represent conclusive proof, an intriguing picture is emerging from a variety of research approaches. These approaches include the observation of minor physical anomalies, premorbid neuropsychological and social deficits, obstetrical complications, and exposure to adverse intrauterine events. Morphometric brain measurement techniques and neuropathological studies have perhaps provided more substantial support.
ISSN:0959-4388
1873-6882
DOI:10.1016/S0959-4388(98)80019-6