Comparison of Tc-99m MAG3 and Tc-99m DTPA in Renal Transplant Patients with Impaired Renal Function

Tc-99m mercaptoacetyltriglycine (MAG3) is a new Tc-99m renal agent that compares favorably to I-131 Hippuran in animal models, normal volunteers, and patients. Based on the fact that Tc-99m MAG3 has a much more rapid clearance than Tc-99m DTPA and a smaller volume of distribution, it was postulated...

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Bibliographic Details
Published in:Clinical nuclear medicine 1990-06, Vol.15 (6), p.371-378
Main Authors: TAYLOR, ANDREW, ZIFFER, JACK A, ESHIMA, DENNIS
Format: Article
Language:English
Subjects:
Adult
Female
Graft Rejection
Humans
Kidney Diseases - diagnostic imaging
Kidney Diseases - physiopathology
Kidney Transplantation
Male
Oligopeptides
Organotechnetium Compounds
Pentetic Acid
Radionuclide Imaging
Technetium Tc 99m Mertiatide
Technetium Tc 99m Pentetate
Uremia - diagnostic imaging
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Summary:Tc-99m mercaptoacetyltriglycine (MAG3) is a new Tc-99m renal agent that compares favorably to I-131 Hippuran in animal models, normal volunteers, and patients. Based on the fact that Tc-99m MAG3 has a much more rapid clearance than Tc-99m DTPA and a smaller volume of distribution, it was postulated that the image quality of Tc-99m MAG3 studies should be superior to scans obtained using Tc-99m DTPA, particularly in patients with impaired renal function. To test this hypothesis, Tc-99m DTPA and MAG3 images were obtained in three transplant patients during periods of stable but impaired renal function. In one study, the Tc-99m DTPA study was potentially misleading, whereas the Tc-99m MAG3 examination assessed the clinical situation correctly. In all three cases, the Tc-99m MAG3 images were superior.
ISSN:0363-9762
1536-0229
DOI:10.1097/00003072-199006000-00001