Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy

Treatment of portal hypertension by portal decompressive surgery or transjugular intrahepatic portosystemic stent shunt (TIPS) results in new or worsening episodes of portal-systemic encephalopathy, particularly in older patients. As part of a series of studies to elucidate the pathophysiologic mech...

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Bibliographic Details
Published in:Metabolic brain disease 1998-03, Vol.13 (1), p.69-78
Main Authors: Audet, R M, Butterworth, R F
Format: Article
Language:English
Subjects:
Age Factors
Animals
Blood Glucose - analysis
Brain - metabolism
Cerebrovascular Circulation
Glucose - metabolism
Hepatic Encephalopathy - etiology
Portacaval Shunt, Surgical - adverse effects
Rats
Rats, Sprague-Dawley
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Summary:Treatment of portal hypertension by portal decompressive surgery or transjugular intrahepatic portosystemic stent shunt (TIPS) results in new or worsening episodes of portal-systemic encephalopathy, particularly in older patients. As part of a series of studies to elucidate the pathophysiologic mechanisms responsible for the age-related increased portal-systemic encephalopathy following shunt surgery, local cerebral glucose utilization, a measure of regional brain functional activity, was assessed using the 14C-2-deoxyglucose autoradiographic technique in 2 month-old (young adult) and 24 month-old (old adult) rats following end-to-side portacaval anastomosis. Cerebral glucose utilization was decreased by 22% (p
ISSN:0885-7490
DOI:10.1023/A:1020683013238