Conditional associative learning and the hippocampal system

Rats with lesions of the fornix, the dorsal hippocampus, or a control operation were trained on a spatial‐visual conditional associative learning task in which they had to learn to associate particular locations with specific visual stimuli. Animals with damage of the fornix were able to learn the t...

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Bibliographic Details
Published in:Hippocampus 1998, Vol.8 (2), p.131-137
Main Authors: Sziklas, V., Lebel, S., Petrides, M.
Format: Article
Language:English
Subjects:
Animals
Association Learning - physiology
Brain Mapping
fornix
hippocampus
Hippocampus - injuries
Hippocampus - pathology
Hippocampus - physiology
Male
Maze Learning - physiology
Memory - physiology
Rats
Space Perception - physiology
spatial learning
Time Factors
Visual Perception - physiology
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Summary:Rats with lesions of the fornix, the dorsal hippocampus, or a control operation were trained on a spatial‐visual conditional associative learning task in which they had to learn to associate particular locations with specific visual stimuli. Animals with damage of the fornix were able to learn the task at a rate comparable to that of the control animals, but the performance of the hippocampal rats was significantly impaired in comparison with that of both the control and the fornix groups. In a second experiment, lesions to the fornix or the dorsal hippocampus significantly impaired performance on a spatial working memory task, the eight‐arm radial maze. These findings suggest that the interaction between the hippocampus and subcortical structures via the fornix may be critical only for certain types of spatial learning and memory. Hippocampus 1998;8:131–137. © 1998 Wiley‐Liss, Inc.
ISSN:1050-9631
1098-1063
DOI:10.1002/(SICI)1098-1063(1998)8:2<131::AID-HIPO5>3.0.CO;2-O