Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime

• Published in: Journal of antimicrobial chemotherapy 1998-03, Vol.41 (3), p.407-409
• Main Authors: DE BOECK, K, BREYSEM, L
• Format: Article
• Language: English
• Subjects: Adolescent; Alanine Transaminase - blood; Alanine Transaminase - drug effects; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Blood Sedimentation - drug effects; Body Weight - drug effects; Ceftazidime - administration & dosage; Ceftazidime - therapeutic use; Cephalosporins - administration & dosage; Cephalosporins - therapeutic use; Child; Creatinine - blood; Cystic Fibrosis - complications; Cystic Fibrosis - microbiology; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume - drug effects; Forced Expiratory Volume - physiology; Hemoglobins - drug effects; Hemoglobins - metabolism; Humans; Leukocyte Count - drug effects; Lung - drug effects; Lung - microbiology; Lung Diseases - drug therapy; Lung Diseases - microbiology; Lung Diseases - physiopathology; Lung Volume Measurements; Male; Medical sciences; Neutrophils - cytology; Neutrophils - drug effects; Patient Readmission; Pharmacology. Drug treatments; Platelet Count - drug effects; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Pseudomonas Infections - complications; Pseudomonas Infections - drug therapy; Pseudomonas Infections - microbiology; Pulmonary Ventilation - drug effects; Pulmonary Ventilation - physiology; Recurrence; Respiratory Function Tests; Time Factors; Treatment Outcome; Veins; Vital Capacity - drug effects; Vital Capacity - physiology
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/41.3.407

In cystic fibrosis patients with Pseudomonas aeruginosa colonization and increasing pulmonary infection, ceftazidime 150 mg/kg/day was compared with 320 mg/kg/day. Changes in clinical findings, laboratory tests, pulmonary function and chest radiographs were evaluated after 14 days of treatment in hospital. Both treatments were associated with a significant improvement, but the higher dose did not offer an additional benefit. An increase in alanine aminotransferase (ALT) occurred after both treatments; with a significantly greater increase after the high-dose therapy (mean increase +/- S.E.M. 8% +/- 2% vs 2% +/- 1 %; P < 0.01). All but one of the ALT values after treatment were within normal limits.