Role of nitric oxide on the central hemodynamic response to acute volume expansion in the pregnant rat

OBJECTIVES: Our hypothesis was that during pregnancy nitric oxide acts as mediator in the hemodynamic response to volume expansion. STUDY DESIGN: The study was performed on 12 rats on days 19 to 20 of pregnancy. Six rats were injected intravenously with hexamethonium bromide plus the inhibitor of ni...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 1998-04, Vol.178 (4), p.823-829
Main Authors: Fiol, Gabriel, Machado, Francisco, Hernandez, Isabel, Inglés, Andrés C., Abad, Lorenzo, Parrilla, Juan J., Meseguer, Juan, Quesada, Tomás, Carbonell, Luis F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Blood Volume - physiology
Cardiac Output
Enzyme Inhibitors - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Ganglionic Blockers - pharmacology
Hematocrit
Hemodynamics - physiology
Hexamethonium - pharmacology
Hormone metabolism and regulation
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
Nitric Oxide - physiology
Nitric Oxide Synthase - antagonists & inhibitors
Pregnancy
Pregnancy, Animal - physiology
Pregnancy. Parturition. Lactation
Pregnant rats
Rats
Rats, Wistar
Sodium Chloride - administration & dosage
Vascular Resistance
Vertebrates: reproduction
volume expansion
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Summary:OBJECTIVES: Our hypothesis was that during pregnancy nitric oxide acts as mediator in the hemodynamic response to volume expansion. STUDY DESIGN: The study was performed on 12 rats on days 19 to 20 of pregnancy. Six rats were injected intravenously with hexamethonium bromide plus the inhibitor of nitric oxide synthase l-nitro-arginine methyl ester. For a control group, six rats were injected with hexamethonium bromide plus the l-nitro-arginine methyl ester vehicle. A volume expansion (1.2% body weight) was performed in both groups by intravenous infusion of bovine albumin (6%) solution. RESULTS: In the control group volume expansion induced a hyperdynamic circulation characterized by increased cardiac output, decreased total vascular resistance, and no change in arterial pressure; however, in the study group volume expansion induced a pressor response without hyperdynamic circulation. CONCLUSION: During pregnancy volume expansion induces a hyperdynamic circulatory state possibly mediated by nitric oxide release. A defect in the release of nitric oxide may be responsible for an inadequate hemodynamic response to volume expansion. (Am J Obstet Gynecol 1998;178:823-9.)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(98)70499-5