Comparative therapeutic efficacy of clinafloxacin in a Pseudomonas aeruginosa mouse renal abscess model

• Published in: Journal of antimicrobial chemotherapy 1998-03, Vol.41 (3), p.403-405
• Main Authors: SHAPIRO, M. A, SESNIE, J. C, DESATY, T. M, GRIFFIN, T. J, HEIFETZ, C. L
• Format: Article
• Language: English
• Subjects: Abscess - drug therapy; Abscess - etiology; Abscess - microbiology; Animals; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - blood; Anti-Infective Agents - therapeutic use; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Area Under Curve; Biological and medical sciences; Ceftazidime - administration & dosage; Ceftazidime - blood; Ceftazidime - pharmacology; Cilastatin - blood; Cilastatin - pharmacology; Cilastatin, Imipenem Drug Combination; Ciprofloxacin - administration & dosage; Ciprofloxacin - blood; Ciprofloxacin - therapeutic use; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Therapy, Combination - blood; Drug Therapy, Combination - pharmacology; Female; Fluoroquinolones; Half-Life; Imipenem - blood; Imipenem - pharmacology; Kidney - drug effects; Kidney - microbiology; Kidney Diseases - drug therapy; Kidney Diseases - etiology; Kidney Diseases - microbiology; Medical sciences; Mice; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Pseudomonas Infections - complications; Pseudomonas Infections - drug therapy; Pseudomonas Infections - microbiology; Quinolones - administration & dosage; Quinolones - blood; Quinolones - therapeutic use; Treatment Outcome
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/41.3.403

A deep-seated Pseudomonas aeruginosa mouse kidney abscess model was used to compare the therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, with that of clinically relevant standard drugs. Following 50 mg/kg oral doses, twice daily for five consecutive days, clinafloxacin produced a 4 log decrease in mean bacterial count, the greatest decrease of all drugs tested. The same dosage regimen resulted in complete bacterial eradication in 88% of the kidneys. No other compound produced total bacterial clearance in 50% of the kidneys at the highest dose tested.