Progressive intermittent claudication is associated with impaired fibrinolysis

Purpose: Acute complications of atherosclerosis such as stroke and myocardial infarction are caused by thrombosis and may be associated with impaired fibrinolytic activity. The current study was performed to determine whether peripheral arterial disease (PAD) and its progression are also associated...

Full description

Saved in:
Bibliographic Details
Published in:Journal of vascular surgery 1998-04, Vol.27 (4), p.645-650
Main Authors: Killewich, Lois A., Gardner, Andrew W., Macko, Richard F., Hanna, Dinah J., Goldberg, Andrew P., Cox, D.Kim, Flinn, William R.
Format: Article
Language:English
Subjects:
Aged
Ankle - blood supply
Arteriosclerosis - complications
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure - physiology
Brachial Artery - physiology
Cardiology. Vascular system
Case-Control Studies
Cerebrovascular Disorders - etiology
Disease Progression
Enzyme-Linked Immunosorbent Assay
Fibrinolysis - physiology
Humans
Intermittent Claudication - blood
Intermittent Claudication - complications
Intermittent Claudication - physiopathology
Leg - blood supply
Male
Medical sciences
Myocardial Infarction - etiology
Pain - physiopathology
Peripheral Vascular Diseases - blood
Peripheral Vascular Diseases - complications
Peripheral Vascular Diseases - physiopathology
Plasminogen Activator Inhibitor 1 - blood
Plasminogen Activators - blood
Regional Blood Flow - physiology
Serine Proteinase Inhibitors - blood
Thrombosis - complications
Tissue Plasminogen Activator - blood
Walking - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose: Acute complications of atherosclerosis such as stroke and myocardial infarction are caused by thrombosis and may be associated with impaired fibrinolytic activity. The current study was performed to determine whether peripheral arterial disease (PAD) and its progression are also associated with impaired fibrinolysis, by measurement of tissue plasminogen activator (tPA, the activator of fibrinolysis) and its inhibitor plasminogen activator inhibitor-1 (PAI-1). Methods: The study group consisted of 80 men with a mean age of 69 years. This included 18 patients with mild intermittent claudication (MC, pain-free walking distance ≥200 meters) and 51 patients with severe claudication (SC, walking distance
ISSN:0741-5214
1097-6809
DOI:10.1016/S0741-5214(98)70229-0