Laparoscopic surgery: The effects of insufflation gas on tumor-induced lethality in nude mice

Objective: The aim of the study was to examine the effect of helium (group 2), carbon dioxide (group 3), and heated carbon dioxide (group 4) pneumoperitoneum on survival in case of intraabdominal spread of tumor cells in nude mice. Study Design: The pneumoperitoneum was induced by a microhysteroflat...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 1998-04, Vol.178 (4), p.793-795
Main Authors: Volz, Joachim, Koster, Stefanie, Schaeff, Beate, Paolucci, Vittorio
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carbon Dioxide
heated carbon dioxide
Helium
Hot Temperature
Humans
Insufflation - adverse effects
intraperitoneal metastases
laparoscopy
Laparoscopy - adverse effects
Lung Neoplasms
Medical sciences
Mesothelioma
Mice
Mice, Nude
Neoplasm Metastasis
Neoplasm Transplantation
oncologic risk
Peritoneal Neoplasms - mortality
Peritoneal Neoplasms - pathology
Pneumoperitoneum
Pneumoperitoneum, Artificial - adverse effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Survival Rate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: The aim of the study was to examine the effect of helium (group 2), carbon dioxide (group 3), and heated carbon dioxide (group 4) pneumoperitoneum on survival in case of intraabdominal spread of tumor cells in nude mice. Study Design: The pneumoperitoneum was induced by a microhysteroflator with an intraperitoneal pressure of 8 mm Hg for 30 minutes. A washed tumor solution (0.4 ml) of a mesothelioma was injected intraperitoneally. Results: The survival rate of group 3 was significantly reduced compared with the controls (group 1) and group 4. The latter groups showed similar survival rates. In groups 2 and 3 no significant differences in survival rate were observed. Conclusion: Clinical observations and the results of this animal study warn against the use of standard unheated carbon dioxide pneumoperitoneum in case of malignant tumors. Heated carbon dioxide seems to be advantageous. (Am J Obstet Gynecol 1998;178:793-5.)
ISSN:0002-9378
1097-6868
DOI:10.1016/S0002-9378(98)70494-6