POTENTIAL THERAPEUTIC VALUE OF DRUGS INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE: VASCULAR CYTOPROTECTION IN DIABETES MELLITUS

Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme found in large amounts in blood plasma and in vascular smooth muscle. The catalytic activity of this enzyme is elevated in diabetes mellitus and some substrates, such as aminoacetone and methylamine also occur in increased am...

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Bibliographic Details
Published in:Pharmacological research 1998-02, Vol.37 (2), p.87-92
Main Author: EKBLOM, JONAS
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - antagonists & inhibitors
Amine Oxidase (Copper-Containing) - blood
Blood Vessels - drug effects
Diabetes Mellitus - drug therapy
Diabetes Mellitus - enzymology
Enzyme Inhibitors - therapeutic use
Humans
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Summary:Semicarbazide-sensitive amine oxidase (SSAO) is a copper-containing enzyme found in large amounts in blood plasma and in vascular smooth muscle. The catalytic activity of this enzyme is elevated in diabetes mellitus and some substrates, such as aminoacetone and methylamine also occur in increased amounts in this disease. After deamination by SSAO highly angiotoxic products are formed, methylglyoxal and formaldehyde, respectively. Moreover, hydrogen peroxide is also formed as a side-product. These products arising from SSAO-catalysed reactions may partially explain late-diabetic damages in the kidneys, eyes and peripheral nerves, as well as other cardiovascular disorders. It is therefore proposed that inhibition of SSAO may decrease the formation of these cytotoxic products and therefore prevent or slow the development of late-diabetic complications.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1997.0272