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REDUNDANT DOWN-REGULATION PATHWAYS FOR p53

The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative\dephosphorylative regulation o...

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Bibliographic Details
Published in:Pharmacological research 1998-02, Vol.37 (2), p.83-85
Main Authors: CINELLI, MARINA, MAGNELLI, LUCIA, CHIARUGI, VINCENZO
Format: Article
Language:English
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Summary:The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative\dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed.
ISSN:1043-6618
1096-1186
DOI:10.1006/phrs.1997.0269