REDUNDANT DOWN-REGULATION PATHWAYS FOR p53

The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative\dephosphorylative regulation o...

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Published in:Pharmacological research 1998-02, Vol.37 (2), p.83-85
Main Authors: CINELLI, MARINA, MAGNELLI, LUCIA, CHIARUGI, VINCENZO
Format: Article
Language:English
Subjects:
Animals
calpain, ubiquitin, p53
Down-Regulation - physiology
Gene Expression Regulation - physiology
Humans
Isomerism
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
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container_title Pharmacological research
container_volume 37
creator CINELLI, MARINA
MAGNELLI, LUCIA
CHIARUGI, VINCENZO
description The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative\dephosphorylative regulation of the latent and active p53 isoforms. The mechanisms prolonging p53 half life, following irradiation, are also discussed.
doi_str_mv 10.1006/phrs.1997.0269
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subjects Animals
calpain, ubiquitin, p53
Down-Regulation - physiology
Gene Expression Regulation - physiology
Humans
Isomerism
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - physiology
title REDUNDANT DOWN-REGULATION PATHWAYS FOR p53
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