Effects of leaf aqueous extract of Bidens pilosa (Asteraceae) on KCl- and norepinephrine-induced contractions of rat aorta

The effect of leaf aqueous extract of Bidens pilosa Linn. on KCl- and norepinephrine-induced contractions of rat aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 60 mM KCl and 10 −5 M norepinephrine were dose-dependently relaxed by the extract, a more s...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1998-03, Vol.60 (2), p.179-182
Main Authors: Dimo, Théophile, Rakotonirina, Silver, Kamgang, René, Tan, Paul V, Kamanyi, Albert, Bopelet, Marc
Format: Article
Language:English
Subjects:
Animals
Aorta - drug effects
Aorta - physiology
Asteraceae - chemistry
Bidens pilosa
Biological and medical sciences
Contraction
General pharmacology
In Vitro Techniques
Medical sciences
Muscle Contraction - drug effects
Norepinephrine - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Leaves - chemistry
potassium chloride
Potassium Chloride - pharmacology
Rat aortic strips
Rats
Rats, Wistar
Relaxation
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Summary:The effect of leaf aqueous extract of Bidens pilosa Linn. on KCl- and norepinephrine-induced contractions of rat aortic strips was studied. In aortic strips with endothelium intact, contractions induced using 60 mM KCl and 10 −5 M norepinephrine were dose-dependently relaxed by the extract, a more significant effect being seen with norepinephrine-induced contractions. Following mechanical damage to the aortic endothelium, inhibition of contractions was more prominent (105%) with the norepinephrine-induced contractions compared with KCl-induced contractions (15%) when the maximal dose (8 mg/ml) of the extract was used. The results suggest that the relaxation effect of the extract may be due to the blockade of the influx of extracellular Ca 2+ into the cell.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(97)00142-6