Compensatory Renal Growth: Role of Growth Hormone and Insulin-Like Growth Factor-I

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 1990, Vol.5 (2), p.123-129
• Main Authors: El Nahas, A. M., Le Carpentier, J. E., Bassett, A. H.
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Animals; Biological and medical sciences; Compensatory renal growth (CRG); Dietary Proteins - pharmacology; Dwarf rats; Growth hormone (GH); Growth Hormone - deficiency; Growth Hormone - physiology; High protein diet (HPD); Insulin-Like Growth Factor I - physiology; Insulin-like growth factor-I (IGF-I); Kidney - physiology; Male; Medical sciences; Nephrectomy - methods; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Somatomedins - physiology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/ndt/5.2.123

Recent experimental evidence suggests that insulin-like growth factor-I (IGF-I) may be involved in compensatory renal growth (CRG). This study was designed to determine the relative contribution of IGF-I and growth hormone (GH) to the CRG that takes place in rats following uninephrectomy (UNx). We also studied the respective role of GH and IGF-I in the stimulation of CRG induced by a high protein diet (HPD). CRG was studied 7 days after UNx in Wistar rats and in a new mutant strain of dwarf rats, selectively deficient in GH. Prior to UNx, rats of both strains were pre-fed (14 days) either a medium-protein diet (MPD, casein 18%) or a HPD (54%). On MPD, CRG was comparable in Wistar (17.6± 3.1%, M ± SD) and dwarf (14.4 ± 4.8%) rats. The HPD enhanced CRG in the Wistars (27±3.9%, P