Placement in a novel environment induces Fos-like immunoreactivity in supramammillary cells projecting to the hippocampus and midbrain

Injections of fluorescent retrograde tracers into either the hippocampal formation or the midbrain raphe nuclei resulted in retrograde labeling of many cells in the supramammillary region of the hypothalamus. Double labeling studies indicated that these two projections originate from different popul...

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Bibliographic Details
Published in:Brain research 1998-04, Vol.789 (2), p.331-334
Main Authors: Wirtshafter, David, Stratford, Thomas R, Shim, Insop
Format: Article
Language:English
Subjects:
Anatomical correlates of behavior
Animals
Arousal
Behavioral psychophysiology
Biological and medical sciences
c- fos
Double labeling
Environment
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - physiopathology
Hypothalamus
Immediate early gene
Immunohistochemistry
Male
Mammillary Bodies - metabolism
Mammillary Bodies - pathology
Mammillary Bodies - physiopathology
Mesencephalon - physiopathology
Neurons - cytology
Neurons - metabolism
Neurons - physiology
Proto-Oncogene Proteins c-fos - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Raphe nuclei
Raphe Nuclei - physiopathology
Rats
Rats, Sprague-Dawley
Stress
Stress, Physiological - physiopathology
Supramammillary region
Synaptic Transmission - physiology
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Summary:Injections of fluorescent retrograde tracers into either the hippocampal formation or the midbrain raphe nuclei resulted in retrograde labeling of many cells in the supramammillary region of the hypothalamus. Double labeling studies indicated that these two projections originate from different populations of supramammillary cells. Expression of the proto-oncoprotein Fos could be induced in some retrogradely labeled cells by placing rats in a novel open field before sacrifice. Although seen in both cell types, Fos-like immunoreactivity was significantly more common in supramammillary cells projecting to the hippocampus than in those projecting to the midbrain. These findings suggest that the supramammillary region may contain several populations of neurons which are differentially responsive to certain behavioral manipulations.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(97)01555-2