Growth hormone and placental lactogen: biology, medicine and biotechnology

Molecular cloning gave us access to the gene members of the human growth hormone and placental lactogen multigene family. Genomic sequencing provided clues for the understanding of the origin, functioning and regulation of this family. It has also allowed us to develop new diagnostic approaches for...

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Bibliographic Details
Published in:Gene 1998-04, Vol.211 (1), p.11-18
Main Author: Barrera-Saldaña, Hugo A
Format: Article
Language:English
Subjects:
Evolution, Molecular
Gene evolution
Gene expression
Gene Expression Regulation - genetics
Genomic sequencing
Growth Hormone - genetics
Growth Hormone - physiology
hGH-hPL multigene family
Humans
Mutation - genetics
PCR diagnosis
Placental Lactogen - genetics
Placental Lactogen - physiology
Polymerase Chain Reaction - methods
Protein Engineering
Recombinant HGH
Recombinant Proteins - isolation & purification
Sequence Analysis
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Summary:Molecular cloning gave us access to the gene members of the human growth hormone and placental lactogen multigene family. Genomic sequencing provided clues for the understanding of the origin, functioning and regulation of this family. It has also allowed us to develop new diagnostic approaches for deficiencies of these hormones and to make new biotechnological contributions.
ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(98)00092-4