The search for orally active medications through combinatorial chemistry

The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug‐like molecules. Published libraries are evaluated in particular for the likelihood th...

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Bibliographic Details
Published in:Medicinal research reviews 1998-05, Vol.18 (3), p.149-185
Main Authors: Fecik, Robert A., Frank, Kristine E., Gentry, Elmer J., Menon, Sanjay R., Mitscher, Lester A., Telikepalli, Hanumaiah
Format: Article
Language:English
Subjects:
absorption
Administration, Oral
Biological and medical sciences
Biological Availability
Chemistry, Pharmaceutical - methods
combinatorial chemistry
distribution
Drug Design
excretion
General pharmacology
heterocyclic centroids
Medical sciences
metabolism
oral activity
Pharmacokinetics
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Structure-Activity Relationship
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Summary:The literature of combinatorial chemistry is reviewed with particular attention paid to considerations of absorption, distribution, metabolism and excretion in the design and evaluation of libraries containing drug‐like molecules. Published libraries are evaluated in particular for the likelihood that the products would possess oral bioavailability. © 1998 John Wiley & Sons, Inc. Med. Res. Rev., 18, No. 3, 149–185, 1998.
ISSN:0198-6325
1098-1128
DOI:10.1002/(SICI)1098-1128(199805)18:3<149::AID-MED2>3.0.CO;2-X