Mechanisms of Neutrophil‐Mediated Killing of Endothelial Cells

The killing of endothelial cells either by activated neutrophils or by addition of H sub(2)O sub(2) has been extensively studied. Several different, important themes related to the mechanism of cell killing have recently emerged. 1) Depending on their origin, the susceptibility of endothelial cells...

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Bibliographic Details
Published in:Journal of leukocyte biology 1990-07, Vol.48 (1), p.97-102
Main Authors: Ward, Peter A., Varani, James
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Communication - physiology
Cell Survival - physiology
Endothelium, Vascular - cytology
Endothelium, Vascular - physiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Monocytes, macrophages
Myeloid cells: ontogeny, maturation, markers, receptors
Neutrophils - physiology
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Summary:The killing of endothelial cells either by activated neutrophils or by addition of H sub(2)O sub(2) has been extensively studied. Several different, important themes related to the mechanism of cell killing have recently emerged. 1) Depending on their origin, the susceptibility of endothelial cells to oxidant-mediated killing by neutrophils varies. 2) In some respects, the killing of endothelial cells by activated neutrophils involves a participation of endothelial cells in their own destruction. 3) The killing of endothelial cells by products of neutrophils does not occur by a single, commonly accepted biochemical event. 4) Endothelial cell killing appears to be mediated by synergistic interaction of oxygen products and proteases from leukocytes. 5) Finally, endothelial cells can be modified by contact with cytokines such that their susceptibility to killing by neutrophils is greatly enhanced.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.48.1.97