Paracentric inversion inv(11) (q21q23) in the Netherlands

We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant...

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Bibliographic Details
Published in:Human genetics 1990-06, Vol.85 (1), p.15-20
Main Authors: MADAN, K, PIETERS, M. H. E. C, SMEETS, D. F. C. M, KUYT, L. P, VAN ASPEREN, C. J, DE PATER, J. M, HAMERS, A. J. H, GERSSEN-SCHOORL, K. B. J, HUSTINX, T. W. J, BREED, A. S. P. M, VAN HEMEL, J. O
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - epidemiology
Abortion, Spontaneous - genetics
Biological and medical sciences
Chromosome aberrations
Chromosome Aberrations - diagnosis
Chromosome Aberrations - epidemiology
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosome Inversion
Chromosomes, Human, Pair 11
Female
Genetic Carrier Screening
Humans
Male
Medical genetics
Medical sciences
Netherlands - epidemiology
Pedigree
Phenotype
population genetics
Pregnancy
Prenatal Diagnosis
Sex Factors
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Summary:We report the result of investigations from 20 families with 72 carriers of the paracentric inversion inv(11)(q21q23) in the Netherlands. There is no increase in the rate of spontaneous abortions among carriers of the inversion or their partners. Also, so far, there are no children with recombinant chromosomes arising from the inversion. It is doubtful whether prenatal diagnosis would be helpful to carriers of this inversion. The results of the genealogy study and geographical distribution are discussed; it is suggested that all the families have arisen from a single mutation.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00276319