Relevance of Anti-nef Antibody Detection as an Early Serologic Marker of Human Immunodeficiency Virus Infection

The relevance, previously suggested by some authors, of anti-nef antibody detection as an early marker of human immunodeficiency virus (HIV) infection was examined with a sensitive liquid phase radioimmunoassay by investigating: (1) the kinetics of appearance of anti-nef antibodies in a set of 77 lo...

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Bibliographic Details
Published in:Blood 1990-07, Vol.76 (1), p.257-264
Main Authors: Bahraoui, E., Benjouad, A., Sabatier, J.M., Allain, J.P., Laurian, Y., Montagnier, L., Gluckman, J.C.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - diagnosis
Acquired Immunodeficiency Syndrome - immunology
AIDS/HIV
Amino Acid Sequence
Biological and medical sciences
Biomarkers - blood
Epitopes - immunology
Female
Gene Products, nef - immunology
Genes, nef
HIV Antibodies - analysis
HIV-1 - genetics
HIV-1 - immunology
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Molecular Sequence Data
nef Gene Products, Human Immunodeficiency Virus
Serology
Sexually Transmitted Diseases, Viral - immunology
Viral Regulatory and Accessory Proteins - immunology
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Summary:The relevance, previously suggested by some authors, of anti-nef antibody detection as an early marker of human immunodeficiency virus (HIV) infection was examined with a sensitive liquid phase radioimmunoassay by investigating: (1) the kinetics of appearance of anti-nef antibodies in a set of 77 longitudinal sera collected from 12 HIV-infected donors at the time of seroconversion; and (2) nef serology in a population of 32 HIV seropositive and three seronegative hemophiliacs and their seronegative or seropositive sexual partners. The results obtained showed that anti-nef antibodies could not be detected in the sera tested independently of the appearance of antibodies specific to HIV structural proteins. Thus, the detection of anti-nef antibodies appears to be of little diagnostic value.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V76.1.257.257