Enhanced Production Of Interleukin‐1 And Tumor Necrosis Factor α By Cultured Peripheral Blood Monocytes From Patients With Scleroderma

Cultured peripheral blood mononuclear cells from 20 patients with scleroderma were shown to produce high levels of interleukin‐1α, interleukin‐1β, and tumor necrosis factor α. There were positive correlations between the production of these 3 molecules. Purified monocytes from these patients produce...

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Bibliographic Details
Published in:Arthritis and rheumatism 1990-06, Vol.33 (6), p.893-897
Main Authors: Umehara, Hisanori, Kumagai, Shunichi, Murakami, Masao, Suginoshita, Toshihiko, Tanaka, Koichiro, Hashida, Seiichi, Ishikawa, Eiji, Imura, Hiroo
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cells, Cultured
Enzyme-Linked Immunosorbent Assay
Humans
Immunoradiometric Assay
Interleukin-1 - biosynthesis
Interleukin-1 - blood
Lipopolysaccharides - pharmacology
Medical sciences
Monocytes - metabolism
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - blood
Tumor Necrosis Factor-alpha - biosynthesis
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Summary:Cultured peripheral blood mononuclear cells from 20 patients with scleroderma were shown to produce high levels of interleukin‐1α, interleukin‐1β, and tumor necrosis factor α. There were positive correlations between the production of these 3 molecules. Purified monocytes from these patients produced much more tumor necrosis factor α than did those from normal subjects, even without lipopolysaccharide stimulation. These results show the hyperactivity of monocytes from scleroderma patients.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780330619