Extraction of [ 18F]fluoride from [ 18O]water by a fast fibrous anion exchange resin

[ 18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K 2CO 3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [ 18F]fluo...

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Bibliographic Details
Published in:International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1990, Vol.41 (6), p.583-586
Main Authors: Jewett, Douglas M., Toorongian, Steven A., Bachelor, Michael A., Kilbourn, Michael R.
Format: Article
Language:English
Subjects:
Anion Exchange Resins
Fluorine Radioisotopes - isolation & purification
Oxygen Isotopes
Water - analysis
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Summary:[ 18F]Fluoride for nucleophilic radiofluorination was recovered from target water by trapping on a fibrous anion exchange resin in the hydroxide form and subsequent displacement into wet methanolic K 2CO 3. Extraction into methanol facilitated rapid evaporation and resolubilization of the [ 18F]fluoride as an ion pair. The resin was first dried in situ and rehydrated with [ 18O]H 2O to avoid isotopic dilution of the target water.
ISSN:0883-2889
DOI:10.1016/0883-2889(90)90044-H