Endocrine changes in women conceiving during treatment with an LHRH agonist

We report on eight patients who conceived during pituitary desensitization with buserelin in the Meal phase of the menstrual cycle. Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurre...

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Published in:Human reproduction (Oxford) 1990-05, Vol.5 (4), p.409-412
Main Authors: Isherwood, P.J., Ibrahim, Z.H.Z., Matson, P.L., Morroll, D.R., Burslem, R.W., Lieberman, B.A.
Format: Article
Language:English
Subjects:
Adult
buserelin
Buserelin - pharmacology
Chorionic Gonadotropin - blood
Down-Regulation
early pregnancy
Estradiol - blood
Female
Humans
LHRH agonist
Luteal Phase
Luteinizing Hormone - blood
Pituitary Gland - drug effects
Pregnancy - blood
Pregnancy - physiology
Progesterone - blood
Retrospective Studies
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cited_by cdi_FETCH-LOGICAL-c358t-d86ccc8ca129ac2bfe6ca545f9f6e6838a49e5c214e240b46a1e5e5ec65a0f4b3
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container_end_page 412
container_issue 4
container_start_page 409
container_title Human reproduction (Oxford)
container_volume 5
creator Isherwood, P.J.
Ibrahim, Z.H.Z.
Matson, P.L.
Morroll, D.R.
Burslem, R.W.
Lieberman, B.A.
description We report on eight patients who conceived during pituitary desensitization with buserelin in the Meal phase of the menstrual cycle. Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurred in conjunction with increasing production of ovarian steroid hormones. Serum concentrations of human chorionic gonadotrophin (HCG) were
doi_str_mv 10.1093/oxfordjournals.humrep.a137112
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Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurred in conjunction with increasing production of ovarian steroid hormones. Serum concentrations of human chorionic gonadotrophin (HCG) were &lt;10 IU/l on day 1 of buserelin administration for seven of the eight patients. The serum concentration of HCG on day 12 showed a median value of 722 IU/l (range 14.6–798 IU/l). Five of the eight patients were given HCG support (10 000 IU) following the diagnosis of pregnancy—three of these patients have ongoing pregnancies and the remaining two had blighted ova on scan. Of the remaining three patients, one had a singleton pregnancy which miscarried at 9 weeks, one had a blighted ovum on scan and bled per vagina shortly after this, and one bled per vagina prior to a scan being carried out. Our results show that pregnancy can occur during pituitary desensitization with buserelin, despite patients being counselled not to have unprotected intercourse in the cycle during which administration commences. An HCG assay on day 1 of buserelin administration is not helpful. 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Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurred in conjunction with increasing production of ovarian steroid hormones. Serum concentrations of human chorionic gonadotrophin (HCG) were &lt;10 IU/l on day 1 of buserelin administration for seven of the eight patients. The serum concentration of HCG on day 12 showed a median value of 722 IU/l (range 14.6–798 IU/l). Five of the eight patients were given HCG support (10 000 IU) following the diagnosis of pregnancy—three of these patients have ongoing pregnancies and the remaining two had blighted ova on scan. Of the remaining three patients, one had a singleton pregnancy which miscarried at 9 weeks, one had a blighted ovum on scan and bled per vagina shortly after this, and one bled per vagina prior to a scan being carried out. Our results show that pregnancy can occur during pituitary desensitization with buserelin, despite patients being counselled not to have unprotected intercourse in the cycle during which administration commences. An HCG assay on day 1 of buserelin administration is not helpful. Pregnancy should be suspected when ovarian steroid production persists despite complete pituitary down-regulation.</description><subject>Adult</subject><subject>buserelin</subject><subject>Buserelin - pharmacology</subject><subject>Chorionic Gonadotropin - blood</subject><subject>Down-Regulation</subject><subject>early pregnancy</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Humans</subject><subject>LHRH agonist</subject><subject>Luteal Phase</subject><subject>Luteinizing Hormone - blood</subject><subject>Pituitary Gland - drug effects</subject><subject>Pregnancy - blood</subject><subject>Pregnancy - physiology</subject><subject>Progesterone - blood</subject><subject>Retrospective Studies</subject><issn>0268-1161</issn><issn>1460-2350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNpVkE1LJDEQhoMoOqv7E4Rc9NZjKl-dPngQ0Z11BwRRWPYSMunqmdbpZEy6V_ffb8sMgtShCt63vh5CzoBNgVXiIr43MdXPcUjBrfN0NXQJN1MHogTge2QCUrOCC8X2yYRxbQoADUfkW87PjI2l0YfkkAOIipsJ-XUT6uhTG5D6lQtLzLQN9C12GKiPwWP7tw1LWg_pI_UJXT9KPX1r-xV1gc5nDzPqljG0uT8hB814En7f5WPydHvzeD0r5vc_fl5fzQsvlOmL2mjvvfEOeOU8XzSovVNSNVWjURthnKxQeQ4SuWQLqR2gGsNr5VgjF-KYnG_nblJ8HTD3tmuzx_XaBYxDtmVllFGyHI2XW6NPMeeEjd2ktnPpnwVmP2DarzDtFqbdwRz7T3eLhkWH9Wf3jt6oF1t9fB7fP2WXXqwuRans7PcfC0I9VvIO7K34D0HkiLY</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Isherwood, P.J.</creator><creator>Ibrahim, Z.H.Z.</creator><creator>Matson, P.L.</creator><creator>Morroll, D.R.</creator><creator>Burslem, R.W.</creator><creator>Lieberman, B.A.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>Endocrine changes in women conceiving during treatment with an LHRH agonist</title><author>Isherwood, P.J. ; Ibrahim, Z.H.Z. ; Matson, P.L. ; Morroll, D.R. ; Burslem, R.W. ; Lieberman, B.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-d86ccc8ca129ac2bfe6ca545f9f6e6838a49e5c214e240b46a1e5e5ec65a0f4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>buserelin</topic><topic>Buserelin - pharmacology</topic><topic>Chorionic Gonadotropin - blood</topic><topic>Down-Regulation</topic><topic>early pregnancy</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Humans</topic><topic>LHRH agonist</topic><topic>Luteal Phase</topic><topic>Luteinizing Hormone - blood</topic><topic>Pituitary Gland - drug effects</topic><topic>Pregnancy - blood</topic><topic>Pregnancy - physiology</topic><topic>Progesterone - blood</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isherwood, P.J.</creatorcontrib><creatorcontrib>Ibrahim, Z.H.Z.</creatorcontrib><creatorcontrib>Matson, P.L.</creatorcontrib><creatorcontrib>Morroll, D.R.</creatorcontrib><creatorcontrib>Burslem, R.W.</creatorcontrib><creatorcontrib>Lieberman, B.A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human reproduction (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isherwood, P.J.</au><au>Ibrahim, Z.H.Z.</au><au>Matson, P.L.</au><au>Morroll, D.R.</au><au>Burslem, R.W.</au><au>Lieberman, B.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine changes in women conceiving during treatment with an LHRH agonist</atitle><jtitle>Human reproduction (Oxford)</jtitle><addtitle>Hum Reprod</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>5</volume><issue>4</issue><spage>409</spage><epage>412</epage><pages>409-412</pages><issn>0268-1161</issn><eissn>1460-2350</eissn><abstract>We report on eight patients who conceived during pituitary desensitization with buserelin in the Meal phase of the menstrual cycle. Pregnancy was diagnosed between day 12 and 21 of buserelin administration. Analysis of serum luteinizing hormone on day 12 showed that pituitary desensitization occurred in conjunction with increasing production of ovarian steroid hormones. Serum concentrations of human chorionic gonadotrophin (HCG) were &lt;10 IU/l on day 1 of buserelin administration for seven of the eight patients. The serum concentration of HCG on day 12 showed a median value of 722 IU/l (range 14.6–798 IU/l). Five of the eight patients were given HCG support (10 000 IU) following the diagnosis of pregnancy—three of these patients have ongoing pregnancies and the remaining two had blighted ova on scan. Of the remaining three patients, one had a singleton pregnancy which miscarried at 9 weeks, one had a blighted ovum on scan and bled per vagina shortly after this, and one bled per vagina prior to a scan being carried out. Our results show that pregnancy can occur during pituitary desensitization with buserelin, despite patients being counselled not to have unprotected intercourse in the cycle during which administration commences. An HCG assay on day 1 of buserelin administration is not helpful. Pregnancy should be suspected when ovarian steroid production persists despite complete pituitary down-regulation.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>2113928</pmid><doi>10.1093/oxfordjournals.humrep.a137112</doi><tpages>4</tpages></addata></record>
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source Oxford University Press Archive
subjects Adult
buserelin
Buserelin - pharmacology
Chorionic Gonadotropin - blood
Down-Regulation
early pregnancy
Estradiol - blood
Female
Humans
LHRH agonist
Luteal Phase
Luteinizing Hormone - blood
Pituitary Gland - drug effects
Pregnancy - blood
Pregnancy - physiology
Progesterone - blood
Retrospective Studies
title Endocrine changes in women conceiving during treatment with an LHRH agonist
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