FR112123, A NEW OLIGOPEPTIDE ANTIBIOTIC FROM STREPTOMYCES VIRIDOCHROMOGENES: TAXONOMY, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL PROPERTIES, STRUCTURE AND BIOLOGICAL ACTIVITY

FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The c...

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Bibliographic Details
Published in:Journal of antibiotics 1990/05/25, Vol.43(5), pp.449-455
Main Authors: FUJIE, AKIHIKO, IWAMOTO, TOSHIRO, SHIGEMATSU, NOBUHARU, EZAKI, MASAMI, HINO, MOTOHIRO, HASHIMOTO, SEIJI, OKUHARA, MASAKUNI, KOHSAKA, MASANOBU, IMANAKA, HIROSHI
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Cell Wall - drug effects
Escherichia coli - drug effects
Escherichia coli - ultrastructure
Female
Fermentation
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Mice
Mice, Inbred ICR
Microbiology
Oligopeptides
Spectrophotometry, Infrared
Streptomyces - growth & development
Streptomyces - metabolism
Streptomyces viridochromogenes
Structure-Activity Relationship
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Summary:FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The compound has a superior activity against an Escherichia coli mutant sensitive to inhibitors of cell wall synthesis, although it has a weak activity against the parent strain. These suggest that FR112123 might act on the biosynthesis of bacterial cell wall.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.449