Metastasizing adenocarcinoma of the female prostate (Skene's paraurethral glands). Histological and immunohistochemical prostate markers studies and first ultrastructural observation

• Published in: Pathology, research and practice research and practice, 1998, Vol.194 (2), p.129-136
• Main Authors: Sloboda, J, Zaviacic, M, Jakubovský, J, Hammar, E, Johnsen, J
• Format: Article
• Language: English
• Subjects: Acid Phosphatase - metabolism; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adenocarcinoma - secondary; Biomarkers, Tumor; Female; Humans; Immunohistochemistry; Lymphatic Metastasis - pathology; Male; Microscopy, Electron; Middle Aged; Prostate - metabolism; Prostate-Specific Antigen - metabolism; Urethral Neoplasms - metabolism; Urethral Neoplasms - pathology
• ISSN: 0344-0338
• DOI: 10.1016/S0344-0338(98)80080-0

The case of a 46-year-old women with well-differentiated adenocarcinoma of the female prostate (Skene's paraurethral glands and ducts) with inguinal metastases is reported. Besides adenocarcinomatous structures, also more solid parts of the tumor and anaplastic regions with dark cells were found on histological examination. Clear cancerous cells were typical for glandular and solid tumor parts. The cancerous cells showed distinct immunohistochemical positivity of prostate specific antigen (PSA) and prostate (specific) acid phosphatase [P(S)AcP]. These are the first published results of electron microscopic examination of formalin fixed tissue showing the ultrastructure of female prostate carcinoma, comparable to that of the male prostate carcinoma. In the female, similar to the male, the prostate carcinoma probably originates from the secretory (luminal) cells of the female prostatic glands.