A Rapid Immunochromatographic Test (ICT) for Diagnosis of Plasmodium falciparum

A field study was conducted to assess the sensitivity and specificity of rapid immunodiagnostic test based on detection of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) in peripheral blood for diagnosis of P. falciparum infection. Evaluation in 173 patients showed that the assay was 98.59...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1998-04, Vol.30 (4), p.257-260
Main Authors: Valecha, Neena, Sharma, V.P, Devi, C.Usha
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chromatography
Cross Reactions
Follow-Up Studies
Human protozoal diseases
Humans
Infectious diseases
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - diagnosis
Malaria, Falciparum - parasitology
Medical sciences
Parasitic diseases
Proteins - analysis
Protozoal diseases
Protozoan Proteins - blood
Reagent Kits, Diagnostic
Sensitivity and Specificity
Tropical medicine
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Summary:A field study was conducted to assess the sensitivity and specificity of rapid immunodiagnostic test based on detection of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2) in peripheral blood for diagnosis of P. falciparum infection. Evaluation in 173 patients showed that the assay was 98.59% sensitive and 97.1% specific. There was no cross-reactivity with P. vivax. The test was positive in few patients who were found to be negative by microscopy showing the presence of antigen after curative chemotherapy. The test is a valuable diagnostic tool for falciparum malaria, especially in emergency/field situations requiring rapid diagnosis.
ISSN:0732-8893
1879-0070
DOI:10.1016/S0732-8893(98)00003-0