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Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma
A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromoso...
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| Published in: | Cancer letters 1998-04, Vol.126 (2), p.119-126 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c389t-b451154ec7988fc5830c9d3070c41f6194892dbdc979e33938b73c8f91e9cdf53 |
| container_end_page | 126 |
| container_issue | 2 |
| container_start_page | 119 |
| container_title | Cancer letters |
| container_volume | 126 |
| creator | Bhugra, Bindu Smolarek, Teresa A Lynch, Roy A Meloni, Aurelia M Sandberg, Avery A Deaven, Larry Menon, Anil G |
| description | A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined. We have generated a contig of overlapping yeast artificial chromosome (YAC) clones approximately 3 Mb in size. Fluorescence in situ hybridization (FISH) analysis showed that this contig spanned the t(12;14) breakpoints in three uterine leiomyomas and that the breakpoints in these tumors occurred within a 1 Mb region. A 30 kb cosmid spanning one of the breakpoints was isolated to set the stage for identifying regions on chromosome 14 that may cause this region to be a preferential site for chromosomal translocation. |
| doi_str_mv | 10.1016/S0304-3835(97)00478-3 |
| format | article |
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Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined. We have generated a contig of overlapping yeast artificial chromosome (YAC) clones approximately 3 Mb in size. Fluorescence in situ hybridization (FISH) analysis showed that this contig spanned the t(12;14) breakpoints in three uterine leiomyomas and that the breakpoints in these tumors occurred within a 1 Mb region. A 30 kb cosmid spanning one of the breakpoints was isolated to set the stage for identifying regions on chromosome 14 that may cause this region to be a preferential site for chromosomal translocation.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(97)00478-3</identifier><identifier>PMID: 9585056</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Biological and medical sciences ; Breakpoint cluster region ; Chromosome 14 ; Chromosomes, Artificial, Yeast - genetics ; Chromosomes, Human, Pair 12 - genetics ; Chromosomes, Human, Pair 14 - genetics ; Cloning, Molecular ; DNA, Neoplasm - genetics ; Female ; Female genital diseases ; Genetic Markers ; Gynecology. Andrology. Obstetrics ; Humans ; Karyotyping ; Leiomyoma - genetics ; Medical sciences ; Polymerase Chain Reaction ; Translocation, Genetic - genetics ; Tumors ; Uterine leiomyoma ; Uterine Neoplasms - genetics</subject><ispartof>Cancer letters, 1998-04, Vol.126 (2), p.119-126</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b451154ec7988fc5830c9d3070c41f6194892dbdc979e33938b73c8f91e9cdf53</citedby><cites>FETCH-LOGICAL-c389t-b451154ec7988fc5830c9d3070c41f6194892dbdc979e33938b73c8f91e9cdf53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2342873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9585056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhugra, Bindu</creatorcontrib><creatorcontrib>Smolarek, Teresa A</creatorcontrib><creatorcontrib>Lynch, Roy A</creatorcontrib><creatorcontrib>Meloni, Aurelia M</creatorcontrib><creatorcontrib>Sandberg, Avery A</creatorcontrib><creatorcontrib>Deaven, Larry</creatorcontrib><creatorcontrib>Menon, Anil G</creatorcontrib><title>Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined. We have generated a contig of overlapping yeast artificial chromosome (YAC) clones approximately 3 Mb in size. Fluorescence in situ hybridization (FISH) analysis showed that this contig spanned the t(12;14) breakpoints in three uterine leiomyomas and that the breakpoints in these tumors occurred within a 1 Mb region. A 30 kb cosmid spanning one of the breakpoints was isolated to set the stage for identifying regions on chromosome 14 that may cause this region to be a preferential site for chromosomal translocation.</description><subject>Biological and medical sciences</subject><subject>Breakpoint cluster region</subject><subject>Chromosome 14</subject><subject>Chromosomes, Artificial, Yeast - genetics</subject><subject>Chromosomes, Human, Pair 12 - genetics</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Cloning, Molecular</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Genetic Markers</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Karyotyping</subject><subject>Leiomyoma - genetics</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Translocation, Genetic - genetics</subject><subject>Tumors</subject><subject>Uterine leiomyoma</subject><subject>Uterine Neoplasms - genetics</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkE1r3DAQhkVpSLdpf0JAh1LSgxPJkizpVMLSL1jIIclZyONxqsSWtpIdyL-PN7vstSCYw_vMq-Eh5JyzS854c3XLBJOVMEJdWP2NMalNJd6RFTe6rrQ17D1ZHZEP5GMpj4wxJbU6JadWGcVUsyKb9ZBiiA809dTTNqN_2qYQJwrDXCbMNONDSJEuD_7mNKaSRqRc0hDpvOQhIh0wpPEljf4TOen9UPDzYZ6R-58_7ta_q83Nrz_r600FwtipaqXiXEmE5UrTgzKCge0E0wwk7xtupbF113ZgtUUhrDCtFmB6y9FC1ytxRr7ue7c5_ZuxTG4MBXAYfMQ0F7f0NqZWzQKqPQg5lZKxd9scRp9fHGduZ9G9WXQ7Rc5q92bRiWXv_PDB3I7YHbcO2pb8yyH3BfzQZx8hlCNWC1kbvav5vsdwkfEcMLsCASNgFzLC5LoU_nPIK3cIjYs</recordid><startdate>19980424</startdate><enddate>19980424</enddate><creator>Bhugra, Bindu</creator><creator>Smolarek, Teresa A</creator><creator>Lynch, Roy A</creator><creator>Meloni, Aurelia M</creator><creator>Sandberg, Avery A</creator><creator>Deaven, Larry</creator><creator>Menon, Anil G</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980424</creationdate><title>Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma</title><author>Bhugra, Bindu ; Smolarek, Teresa A ; Lynch, Roy A ; Meloni, Aurelia M ; Sandberg, Avery A ; Deaven, Larry ; Menon, Anil G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-b451154ec7988fc5830c9d3070c41f6194892dbdc979e33938b73c8f91e9cdf53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Breakpoint cluster region</topic><topic>Chromosome 14</topic><topic>Chromosomes, Artificial, Yeast - genetics</topic><topic>Chromosomes, Human, Pair 12 - genetics</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Cloning, Molecular</topic><topic>DNA, Neoplasm - genetics</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Genetic Markers</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Karyotyping</topic><topic>Leiomyoma - genetics</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Translocation, Genetic - genetics</topic><topic>Tumors</topic><topic>Uterine leiomyoma</topic><topic>Uterine Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhugra, Bindu</creatorcontrib><creatorcontrib>Smolarek, Teresa A</creatorcontrib><creatorcontrib>Lynch, Roy A</creatorcontrib><creatorcontrib>Meloni, Aurelia M</creatorcontrib><creatorcontrib>Sandberg, Avery A</creatorcontrib><creatorcontrib>Deaven, Larry</creatorcontrib><creatorcontrib>Menon, Anil G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhugra, Bindu</au><au>Smolarek, Teresa A</au><au>Lynch, Roy A</au><au>Meloni, Aurelia M</au><au>Sandberg, Avery A</au><au>Deaven, Larry</au><au>Menon, Anil G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1998-04-24</date><risdate>1998</risdate><volume>126</volume><issue>2</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>A recurrent reciprocal chromosomal translocation, t(12;14)(q15;q24) is frequently observed in uterine leiomyoma. Chromosome 12 breakpoints have been shown to occur in a region of approximately 150 kb that contains the gene for a high mobility group protein (HMGI-C). The breakpoint region on chromosome 14 has not been precisely defined. We have generated a contig of overlapping yeast artificial chromosome (YAC) clones approximately 3 Mb in size. Fluorescence in situ hybridization (FISH) analysis showed that this contig spanned the t(12;14) breakpoints in three uterine leiomyomas and that the breakpoints in these tumors occurred within a 1 Mb region. A 30 kb cosmid spanning one of the breakpoints was isolated to set the stage for identifying regions on chromosome 14 that may cause this region to be a preferential site for chromosomal translocation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9585056</pmid><doi>10.1016/S0304-3835(97)00478-3</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1998-04, Vol.126 (2), p.119-126 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79868256 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Biological and medical sciences Breakpoint cluster region Chromosome 14 Chromosomes, Artificial, Yeast - genetics Chromosomes, Human, Pair 12 - genetics Chromosomes, Human, Pair 14 - genetics Cloning, Molecular DNA, Neoplasm - genetics Female Female genital diseases Genetic Markers Gynecology. Andrology. Obstetrics Humans Karyotyping Leiomyoma - genetics Medical sciences Polymerase Chain Reaction Translocation, Genetic - genetics Tumors Uterine leiomyoma Uterine Neoplasms - genetics |
| title | Cloning of a breakpoint cluster region on chromosome 14 in uterine leiomyoma |
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