Loss of RB expression in an ACTH-secreting pituitary carcinoma

Little is known about the molecular mechanisms of tumor progression in the pituitary. However, animal studies suggest that the Rb gene may be involved in the development of pituitary carcinoma. Pathologic examination of a pituitary tumor that included both benign and malignant components provided in...

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Bibliographic Details
Published in:Cancer letters 1998-04, Vol.126 (2), p.209-214
Main Authors: Hinton, David R, Hahn, Jeffrey A, Weiss, Martin H, Couldwell, William T
Format: Article
Language:English
Subjects:
Adrenocorticotrophic hormone
Adrenocorticotropic Hormone - metabolism
Biological and medical sciences
Carcinoma - metabolism
Carcinoma - pathology
Cushing disease
Cushing Syndrome - metabolism
Cushing Syndrome - pathology
Disease Progression
Endocrinopathies
Female
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Malignant tumors
Medical sciences
Middle Aged
Neoplasm Proteins - metabolism
Pituitary adenoma
Pituitary carcinoma
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Rb gene
Retinoblastoma Protein - metabolism
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Summary:Little is known about the molecular mechanisms of tumor progression in the pituitary. However, animal studies suggest that the Rb gene may be involved in the development of pituitary carcinoma. Pathologic examination of a pituitary tumor that included both benign and malignant components provided insight into this mechanism. Both benign and malignant tumors were immunoreactive for ACTH. The benign adenoma showed strong nuclear immunoreactivity for Rb, however, both the adjacent sellar carcinoma and its metastases were Rb-negative. This study suggests that loss of Rb may in some cases be important in the progression of pituitary adenoma to carcinoma.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(98)00013-5