New combined treatment of surgery, radiotherapy, and reconstruction in head and neck rhabdomyosarcoma in children: The amore protocol

• Published in: Head & neck 1998-07, Vol.20 (4), p.283-292
• Main Authors: Schouwenburg, Paul F., Kupperman, David, Bakker, Frans P., Blank, Leo E. C. M., de Boer, Hans B., Voûte, Tom A.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Brachytherapy; Child, Preschool; Combined Modality Therapy; combined modality treatment; Female; Gutta-Percha; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - radiotherapy; Head and Neck Neoplasms - surgery; Head and Neck Neoplasms - therapy; Humans; Male; Medical sciences; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Radiotherapy Dosage; reconstructive surgery; rhabdomyosarcoma; Rhabdomyosarcoma - drug therapy; Rhabdomyosarcoma - radiotherapy; Rhabdomyosarcoma - surgery; Rhabdomyosarcoma - therapy; surgery in head and neck; Treatment Outcome; Tumors
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/(SICI)1097-0347(199807)20:4<283::AID-HED1>3.0.CO;2-V

Background If no complete remission on chemotherapy is reached in head and neck rhabdomyosarcoma (RMS) in children, adjuvant radiotherapy and/or surgery are indicated. This often causes severe mutilation, and the prognosis is poor. Ablative surgery, moulage technique with afterloading brachytherapy, and reconstructive surgery, called the AMORE protocol, is developed for residual or recurrent disease after chemotherapy. Methods Ablative surgery with preservation of important structures is followed by the embedding of a gutta‐percha mold in the created tissue defect. The wound bed is irradiated with Iridium192. Within 1 week, the defect is reconstructed with a muscle transplant. Fifteen children (mean age, 5.7 years) were treated accordingly. Results All patients were discharged within 4 weeks. Eleven patients are tumor‐free, with a mean follow‐up period of 2.8 years. No signs of radiation sequelae were observed. Conclusion The preliminary results of this new, combined treatment are encouraging, if the advanced stage of disease is considered. © 1998 John Wiley & Sons, Inc. Head Neck 20:283–292, 1998.