Mitral regurgitation: Impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans

A number of phosphorus (31P) magnetic resonance spectroscopy (MRS) studies link alterations of high-energy phosphate metabolism in valvular disease and cardiomyopathy to the clinical severity of heart failure. However, correlations between MRS and indexes of ventricular dysfunction are inconclusive...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-05, Vol.97 (17), p.1716-1723
Main Authors: CONWAY, M. A, BOTTOMLEY, P. A, OUWERKERK, R, RADDA, G. K, RAJAGOPALAN, B
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analysis
Adolescent
Adult
Aged
Biological and medical sciences
Cardiology. Vascular system
Echocardiography
Endocardial and cardiac valvular diseases
Female
Heart
Humans
Hypertrophy, Left Ventricular - metabolism
Male
Medical sciences
Middle Aged
Mitral Valve Insufficiency - metabolism
Phosphocreatine - analysis
Systole
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A number of phosphorus (31P) magnetic resonance spectroscopy (MRS) studies link alterations of high-energy phosphate metabolism in valvular disease and cardiomyopathy to the clinical severity of heart failure. However, correlations between MRS and indexes of ventricular dysfunction are inconclusive to date. We examined whether changes in 31P MRS are associated with the impaired contractility, which predisposes to chronic congestive heart failure in patients with mitral regurgitation. Thirteen normal control subjects and 22 patients with echocardiographically characterized chronic mitral regurgitation were studied by 31P MRS. The apical phosphocreatine-to-ATP ratio (PCr/ATP) was lower in severe disease (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.97.17.1716