Vitiligo

The destruction of melanocytes is the cause of depigmented maculae that clinically represent the disease vitiligo . Although the cause is unknown, various theories such as the autoimmune, autocytotoxic, and neural hypotheses have been proposed. Extensive research has provided numerous answers regard...

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 1998-05, Vol.38 (5), p.647-668
Main Author: Kovacs, Stephen O.
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Autoimmune Diseases - pathology
Biological and medical sciences
Cell Death
Cosmetics - therapeutic use
Dermatology
Disease Susceptibility
Furocoumarins - therapeutic use
Humans
Medical sciences
Melanins - biosynthesis
Melanocytes - metabolism
Melanocytes - pathology
Peripheral Nervous System Diseases - complications
Pigmentary diseases of the skin
PUVA Therapy
Skin Transplantation
Vitiligo - etiology
Vitiligo - genetics
Vitiligo - immunology
Vitiligo - pathology
Vitiligo - psychology
Vitiligo - therapy
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Summary:The destruction of melanocytes is the cause of depigmented maculae that clinically represent the disease vitiligo . Although the cause is unknown, various theories such as the autoimmune, autocytotoxic, and neural hypotheses have been proposed. Extensive research has provided numerous answers regarding the pathogenesis, histopathologic evidence, and treatment of vitiligo. This discussion of vitiligo summarizes the varied clinical presentations of the disease, theories attempting to explain the mechanism of melanocyte destruction, histopathologic findings, and different treatment modalities currently available. (J Am Acad Dermatol 1998;38:647-66.) Learning Objective: At the conclusion of this learning activity, participants should be familiar with the clinical and histopathologic presentations of vitiligo, the etiologic hypotheses of the disease, and the treatment options.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(98)70194-X